PO-05-037 EFFICACY AND CLINICAL CHARACTERISTICS OF AVERT-VT: ABLATION AT VIRTUAL-HEART PREDICTED VT

We have previously demonstrated the feasibility of virtual-heart simulations in determining noninvasively optimal infarct-related ventricular tachycardia (VT) ablation targets and guiding clinical ablation. are now proceeding with AVERT-VT, an FDA-approved study for ten prospective patients. To develop end-to-end personalized computational modeling prediction pipeline enabling AVERT-VT to assess corresponding characteristics predicted targets. developed a comprehensive (Fig). 3D LGE-MRI scans 1.5x1.5mm in-plane spatial resolution slice thickness <2mm were used reconstruct left (LV) model incorporating deep scar, border (gray) zone, non-infarcted tissue. In silico rapid pacing from 7 LV regions performed induce VTs. The determined by thorough analyses wavefront propagation induced A linear connecting VT target transmural scar region, basal or other was eliminate potential pathway formed Potential emergent VTs post-ablation substrate investigated repeating induction protocol. This process iterated until complete non-inducibility achieved. initial repeat targets, ablations, as well LV, right ventricle, infarct area, aortic arch, coronary cusp geometries, exported strategy plan compatible mapping system. figure presents results one patient study. successfully imported co-registered patient’s heart. extent corresponded bipolar low-voltage regions. Abnormal electrograms observed at proposed 2 during procedure. Areas latest activation sinus rhythm best pace maps, long stimulus QRS, found One seven not ablated due proximity sided His potential. inducible any end abnormal electrograms, ablating led non-inducibility.